The Denver Broncos (1-1) and San Francisco 49ers (1-1) will meet on Sunday Night Football as part of the Week 3 NFL schedule. The Niners were able to bounce back last week with a win after starting the season 0-1. In Week 2, San Francisco beat Seattle 27-7. Meanwhile, Denver narrowly beat the Houston Texans 16-9 last Sunday. Jimmy Garoppolo is back as the starting quarterback for San Francisco after Trey Lance suffered a season-ending ankle injury in Week 2.
Kickoff is set for 8:20 p.m. ET from Empower Field at Mile High. San Francisco is favored by 1.5 points in the latest 49ers vs. Broncos odds from Caesars Sportsbook, and the over/under is 44. Before making any Broncos vs. 49ers picks, be sure to check out the NFL predictions and betting advice from the SportsLine Projection Model.
The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Broncos vs. Niners and just locked in its picks and SNF predictions. You can visit SportsLine now to see the picks. Here are the NFL odds and betting lines for Niners vs. Broncos:
- Broncos vs. 49ers spread: San Francisco -1.5
- Broncos vs. 49ers over/under: 44 points
- Broncos vs. 49ers money line: Denver +105, San Francisco -125
- SF: 49ers are 6-1 ATS in their last seven games overall
- DEN: Under is 6-0 in Broncos’ last six games in September
- Broncos vs. 49ers picks: See picks here
Featured Game | Denver Broncos vs. San Francisco 49ers
Why the Broncos can cover
The Broncos’ offense hasn’t looked the sharpest yet with quarterback Russell Wilson and head coach Nathaniel Hackett calling the shots. Despite their struggles, they are currently ranked eighth in passing yards per game (265.5). Wilson has the arm strength and accuracy to make any throw on the field. The nine-time Pro-Bowler is a menace once the play breaks down due to his outstanding playmaking ability outside of the pocket.
Wilson has thrown for 559 yards with two passing touchdowns through two games. In Week 1, he went 29-of-42 for 340 yards and a passing touchdown. Receiver Courtland Sutton is a strong target on the outside for Denver. Sutton is listed at 6-foot-4 and can soar over defenders and snag contested balls. The 26-year-old is leading the team in receiving yards (194) on 11 receptions. Last week, Sutton came down with seven catches for 122 yards.
Why the 49ers can cover
Head coach Kyle Shanahan loves to run the football and establish the ground game early and often. The Niners can then build play-action off of the run game and take their deep shots downfield. Through two games, San Francisco is fourth in rushing yards per game (182.5). Running back Jeff Wilson Jr. is now the lead man in the backfield with Elijah Mitchell (knee) sidelined.
Wilson Jr. has strong vision to find the open hole and get to the second level. The 25-year-old stepped up last week and had 103 total scrimmage yards, with 84 coming on the ground. Receiver Deebo Samuel is another weapon who takes carries from the backfield. The 2021 Pro Bowler has 12 carries for 105 yards and two touchdowns. He’s also reeled in seven passes for 58 yards.
How to make Broncos vs. 49ers picks
SportsLine’s model is leaning Under on the total, projecting the teams to combine for 42 points. It also says one side of the spread cashes in more than 50 percent of simulations. You can only get the model’s SNF picks at SportsLine.
So who wins 49ers vs. Broncos on Sunday Night Football? And which side of the spread hits over 50 percent of the time? Visit SportsLine now to see which side of the 49ers vs. Broncos spread to jump on, all from the advanced model that is up more than $7,000 on NFL picks, and find out.